Author

R. A. Ruberto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Assay:proteomics· 1

Frequent Co-Authors

J. K. Eaton· 2 shared M. J. Ryan· 2 shared S. L. Schreiber· 2 shared V. S. Viswanathan· 2 shared A. Hilpmann· 1 shared A. Kramm· 1 shared A. L. Eheim· 1 shared B. Bajrami· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

J. K. Eaton

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2 papers

Recent·Most cited

Modulation of ferroptosis sensitivity by TXNRD1 in pancreatic cancer cells

L. L. Cai, R. A. Ruberto, M. J. Ryan, J. K. Eaton, S. L. Schreiber, V. S. Viswanathan

This study shows that reducing TXNRD1 in pancreatic cancer cells increases resistance to ferroptosis by boosting GPX4 levels, highlighting context-specific ferroptosis regulation.

bioRxiv · Jun 25, 2020 · PreprintCell Biology

Targeting a Therapy-Resistant Cancer Cell State Using Masked Electrophiles as GPX4 Inhibitors

J. K. Eaton, L. Furst, R. A. Ruberto, D. Moosmayer, R. C. Hillig, A. Hilpmann, K. Zimmermann, M. J. Ryan, M. Niehues, V. Badock, A. Kramm, S. Chen, P. A. Clemons, S. Gradl, C. Montagnon, , S. L. Schreiber

This paper identifies nitrile oxide electrophiles as a new class of GPX4 inhibitors that overcome limitations of existing chloroacetamide-based inhibitors.

bioRxiv · Sep 5, 2018Biochemistry