Author

L. L. Cai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:mechanistic / dynamical model· 1 Assay:proteomics· 1

Frequent Co-Authors

J. K. Eaton· 2 shared V. S. Viswanathan· 2 shared A. M. Patel· 1 shared E. Pizzi· 1 shared G. Tian· 1 shared G. Xing· 1 shared J. A. S. Roth· 1 shared J. Hynes· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

J. K. Eaton

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Author profile →

2 papers

Recent·Most cited

The enzyme glutamate-cysteine ligase (GCL) is a target for ferroptosis induction in cancer

J. K. Eaton, P. Chatterji, L. Furst, S. Basak, A. M. Patel, Y. Y. Sweat, L. L. Cai, K. Dave, R. A. Victoria, E. Pizzi, J. Noorbakhsh, G. Tian, J. A. S. Roth, J. Hynes, G. Xing, , V. S. Viswanathan

This study identifies GCL inhibition as a strategy to induce ferroptosis in cancer cells, introducing novel inhibitors with potent cellular activity.

bioRxiv · Apr 28, 2024 · PreprintCancer Biology

Modulation of ferroptosis sensitivity by TXNRD1 in pancreatic cancer cells

L. L. Cai, R. A. Ruberto, M. J. Ryan, J. K. Eaton, S. L. Schreiber, V. S. Viswanathan

This study shows that reducing TXNRD1 in pancreatic cancer cells increases resistance to ferroptosis by boosting GPX4 levels, highlighting context-specific ferroptosis regulation.

bioRxiv · Jun 25, 2020 · PreprintCell Biology