Author

A. Meinhart

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Assay:cryo-EM· 2 Research Focus:drug response / drug discovery· 2 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

T. Clausen· 4 shared D. Haselbach· 2 shared R. Kurzbauer· 2 shared A. Bylicki· 1 shared A. Pauli· 1 shared A. Shulkina· 1 shared A. Vogel· 1 shared C. Pribitzer· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersBiochemistry

T. Clausen

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Author profile →

5 papers

Recent·Most cited

Structural basis of how the BIRC6/SMAC complex regulates apoptosis and autophagy

J. F. Ehrmann, D. B. Grabarczyk, M. Heinke, L. Deszcz, R. Kurzbauer, O. Hudecz, A. Shulkina, R. Gogova, A. Meinhart, G. A. Versteeg, T. Clausen

The paper determines the cryo-EM structure of BIRC6 and its complex with HTRA2 and SMAC, revealing how SMAC inhibits BIRC6 to regulate apoptosis and autophagy.

bioRxiv · Aug 30, 2022 · PreprintBiochemistry

UNC-45 assisted myosin folding depends on a conserved FX3HY motif implicated in Freeman Sheldon Syndrome

A. Vogel, R. Arnese, R. Gudino Carrillo, D. Sehr, A. Bylicki, A. Meinhart, T. Clausen

This study identifies the FX3HY motif as essential for UNC-45-mediated myosin folding, linking its disruption to Freeman Sheldon Syndrome and myopathies.

bioRxiv · Aug 8, 2022Biochemistry

A molecular network of conserved factors keeps ribosomes dormant in the egg

K. F. Leesch, L. Lorenzo-Orts, C. Pribitzer, I. Grishkovskaya, M. Matzinger, E. Roitinger, K. Belacic, S. Kandolf, T.-Y. Lin, K. Mechtler, A. Meinhart, D. Haselbach, A. Pauli

The paper identifies conserved factors that maintain ribosome dormancy in zebrafish and Xenopus eggs and embryos, transitioning to an active state during early development.

bioRxiv · Nov 3, 2021Biochemistry

BacPROTACs mediate targeted protein degradation in bacteria

F. E. Morreale, S. Kleine, J. Leodolter, S. Ovchinnikov, J. Kley, R. Kurzbauer, D. M. Hoi, A. Meinhart, M. Hartl, D. Haselbach, M. Kaiser, T. Clausen

This paper develops BacPROTACs, small-molecule degraders that target bacterial proteins by activating the ClpC:ClpP protease, demonstrating in vivo degradation in mycobacteria.

bioRxiv · Jun 9, 2021Biochemistry

Native mass spectrometry can effectively predict PROTAC efficacy

R. Beveridge, D. Kessler, K. Rumpel, P. Ettmayer, A. Meinhart, T. Clausen

This study shows native mass spectrometry can detect PROTAC-mediated protein interactions and identify preferred E3-PROTAC-POI combinations in competition experiments.

bioRxiv · Nov 25, 2019Biochemistry