Distinct eosinophil subsets are modulated by agonists of the commensal-metabolite and vitamin B3 receptor GPR109A during allergic-type inflammation
R. Azzoni, K. J. Filbey, R. H. Daw, M. Z. Krauss, M. R. Hepworth, J. E. Konkel, E. M. Hessel, Y. Kannan, J. R. Grainger
The paper identifies GPR109A as a regulator of glycolytic Siglec-Fhi eosinophils during allergic inflammation, showing that GPR109A ligands reduce their frequency and activation.
bioRxiv · Aug 4, 2022 · PreprintImmunology