Author

J. R. Grainger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. E. Konkel· 2 shared R. H. Daw· 2 shared A. Bateman· 1 shared A. D. Adamson· 1 shared A. J. Harris· 1 shared A. Malbon· 1 shared A. O. Speak· 1 shared A. Schejtman· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersImmunology

J. E. Konkel

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

CD163 and Tim-4 identify resident intestinal macrophages across sub-tissular regions that are spatially regulated by TGF-β

I. E. Prise, V. Jayaraman, V. Kästele, R. H. Daw, K. Wemyss, H. Bridgeman, S. Tamburrano, P. Strangward, C. Chew, L. Martens, C. L. Scott, M. Guilliams, A. D. Adamson, J. E. Konkel, T. N. Shaw, J. R. Grainger

The paper identifies CD163 and Tim-4 as markers for intestinal macrophages and shows TGF-β regulates their spatial distribution in different niches.

bioRxiv · Aug 21, 2023Immunology

Distinct eosinophil subsets are modulated by agonists of the commensal-metabolite and vitamin B3 receptor GPR109A during allergic-type inflammation

R. Azzoni, K. J. Filbey, R. H. Daw, M. Z. Krauss, M. R. Hepworth, J. E. Konkel, E. M. Hessel, Y. Kannan, J. R. Grainger

The paper identifies GPR109A as a regulator of glycolytic Siglec-Fhi eosinophils during allergic inflammation, showing that GPR109A ligands reduce their frequency and activation.

bioRxiv · Aug 4, 2022 · PreprintImmunology

Treatment with IgM-enriched intravenous immunoglobulins (IgM-IVIg) enhances clearance of stroke-associated bacterial lung infection

L. McCulloch, A. J. Harris, A. Malbon, M. J. D. Daniels, M. Younas, J. R. Grainger, S. M. Allan, C. J. Smith, B. W. McColl

This study shows that IgM-enriched intravenous immunoglobulin (IgM-IVIg) improves bacterial clearance and reduces lung inflammation after stroke.

bioRxiv · Dec 16, 2021Immunology

EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling

L. O. Randzavola, P. M. Mortimer, E. C. Garside, E. R. Dufficy, A. Schejtman, G. Roumelioti, L. Yu, M. Pardo, K. Spirohn, C. Tolley, C. Brandt, K. Harcourt, E. Nichols, M. Nahorski, G. Woods, , D. C. Thomas

This study identifies EROS as a chaperone essential for gp91phox maturation and P2X7 receptor function, revealing its role in immune responses and infection resistance.

bioRxiv · Sep 14, 2021Immunology