Author

R. B. Jensen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Approach:microscopy & imaging analysis· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. Cui· 1 shared C. C. Dombrowski· 1 shared E. Rothenberg· 1 shared G. Moore· 1 shared J. C. Bell· 1 shared J. Garbarino· 1 shared J. Jimenez-Sainz· 1 shared J. L. Plank· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperCancer Biology

A. Cui

Author profile →

3 papers

Recent·Most cited

PARG inhibition induces nuclear aggregation of PARylated PARP1

S. Paradkar, J. Purcell, A. Cui, S. Friedman, R. Sundaram, R. B. Jensen, R. S. Bindra

This study shows that PARG inhibition causes PARP1 to aggregate in the nucleus, leading to mis-localization and non-apoptotic cell death.

bioRxiv · Aug 12, 2023Cancer Biology

BRCA2 chaperones RAD51 to single molecules of RPA-coated ssDNA

J. C. Bell, C. C. Dombrowski, J. L. Plank, R. B. Jensen, S. C. Kowalczykowski

This study uses single-molecule techniques to show BRCA2 chaperones RAD51 to RPA-coated ssDNA, overcoming kinetic barriers to promote homologous recombination.

bioRxiv · Dec 28, 2022 · PreprintBiochemistry

BRCA2 BRC missense variants disrupt RAD51-dependent DNA repair

J. Jimenez-Sainz, J. Mathew, G. Moore, S. Lahiri, J. Garbarino, J. P. Eder, E. Rothenberg, R. B. Jensen

This study evaluates three BRCA2 missense variants, showing two disrupt RAD51 binding and DNA repair, while the third is functional and benign.

bioRxiv · Sep 24, 2021Cancer Biology