J. C. Bell

Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T cell receptor signalling.

This study shows that combining oncolytic Maraba virus with PD-1 blockade overcomes resistance in advanced melanoma with a cold tumor microenvironment.

BRCA2 chaperones RAD51 to single molecules of RPA-coated ssDNA

This study uses single-molecule techniques to show BRCA2 chaperones RAD51 to RPA-coated ssDNA, overcoming kinetic barriers to promote homologous recombination.

More than a ligand: PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I interferon pathway.

PD-L1 promotes oncolytic virus infection by inhibiting the type I interferon pathway through a metabolic shift involving enhanced glycolysis and lactate production.

Plant-based expression of SARS-CoV-2 antigens for use in an oral vaccine

The paper evaluates the expression of SARS-CoV-2 RBD in edible plants to identify a candidate for an oral vaccine, finding lettuce as a suitable host.

Engineering genetically-encoded synthetic biomarkers for breath-based cancer detection

This paper develops a breath-based cancer detection system using engineered D-limonene production in tumors, achieving high sensitivity and specificity in mice and predicting human tumor detection limits.

Characterization of Critical Determinants of ACE2-RBD Interaction

This study identifies critical amino acid residues in SARS-CoV-2 RBD and ACE2 that influence binding affinity and neutralization by antibodies and inhibitors.

An easily adopted murine model of distal pancreatectomy for investigating immunotherapy efficacy in resectable pancreatic adenocarcinoma

This paper develops a surgically resectable murine model of pancreatic adenocarcinoma to test immunotherapy efficacy in preclinical studies.