Author

R. B. Realubit

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:drug response / drug discovery· 3 Approach:statistical model· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Califano· 3 shared C. Karan· 3 shared M. J. Alvarez· 2 shared A. Grunn· 1 shared A. T. Fojo· 1 shared B. Losic· 1 shared C. W. Zhou· 1 shared D. Jäger· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersMicrobiology

A. Califano

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Author profile →

3 papers

Recent·Most cited

Network-based identification and pharmacological targeting of host cell master regulators induced by SARS-CoV-2 infection

P. Laise, M. L. Stanifer, G. Bosker, X. Sun, S. Triana, P. Doldan, F. La Manna, M. De Menna, R. B. Realubit, S. Pampou, C. Karan, T. Alexandrov, M. Kruithof-de Julio, A. Califano, S. Boulant, M. J. Alvarez

This study identifies host cell master regulators affected by SARS-CoV-2 and develops a method to find drugs that reverse their inactivation without harming beneficial immune responses.

bioRxiv · Jul 3, 2021Microbiology

The transcriptomic response of cells to a drug combination is more than the sum of the responses to the monotherapies

J. E. L. Diaz, M. E. Ahsen, T. Schaffter, X. Chen, R. B. Realubit, C. Karan, A. Califano, B. Losic, G. Stolovitzky

The paper shows that drug combination transcriptional responses are not simply additive and develops a prediction algorithm with 0.84 AUROC for synergistic combinations.

bioRxiv · Nov 18, 2019Cell Biology

Unbiased Assessment of H-STS cells as high-fidelity models for gastro-enteropancreatic neuroendocrine tumor drug mechanism of action analysis

M. J. Alvarez, P. Yan, M. L. Alpaugh, M. Bowden, E. Sicinska, C. W. Zhou, C. Karan, R. B. Realubit, P. S. Mundi, A. Grunn, D. Jäger, J. A. Chabot, A. T. Fojo, P. E. Oberstein, H. Hibshoosh, , A. Califano

The paper assesses H-STS cells as models for drug mechanism analysis in gastro-enteropancreatic neuroendocrine tumors using molecular criteria rather than histological features.

bioRxiv · Jun 23, 2019 · PreprintCancer Biology