Author

H. Hibshoosh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2

Frequent Co-Authors

A. Califano· 3 shared A. Curiel-Garcia· 2 shared C. F. Palermo· 2 shared H. C. Maurer· 2 shared K. P. Olive· 2 shared L. Tomassoni· 2 shared S. A. Sastra· 2 shared A. Andren· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCancer Biology

A. Califano

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Author profile →

5 papers

Recent·Most cited

Meta-analyses of mouse and human prostate single-cell transcriptomes reveal widespread epithelial plasticity in tissue regression, regeneration, and cancer

L. Aparicio, L. Crowley, J. R. Christin, C. J. Laplaca, H. Hibshoosh, R. Rabadan, M. M. Shen

This study uses scRNA-seq data from mouse and human prostate tissues to show epithelial plasticity in regression, regeneration, and cancer, with findings on cell type origins and AR signaling heterogeneity.

bioRxiv · Jan 30, 2024Cancer Biology

Ras-dependent activation of BMAL2 regulates hypoxic metabolism in pancreatic cancer

A. Curiel-Garcia, S. Holmstrom, C. Castillo, C. F. Palermo, S. A. Sastra, A. Andren, L. Tomassoni, Z. Li, T. LeLarge, I. Sagalovskiy, D. R. Ross, W. Wong, K. Shaw, J. Genkinger, H. Hibshoosh, , K. P. Olive

This study identifies BMAL2 as a KRAS-dependent regulator of hypoxic metabolism in pancreatic cancer, showing it stabilizes HIF1A and destabilizes HIF2A under hypoxia.

bioRxiv · Mar 19, 2023 · PreprintCancer Biology

Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression

M. C. Hasselluhn, A. R. Decker-Farrell, L. Vlahos, D. H. Thomas, A. Curiel-Garcia, H. C. Maurer, U. N. Wasko, L. Tomassoni, S. A. Sastra, C. F. Palermo, T. C. Dalton, A. Ma, F. Li, E. J. Tolosa, H. Hibshoosh, , K. P. Olive

The paper identifies a paracrine signaling cascade involving SHH, WNT, and VEGF that suppresses angiogenesis in pancreatic cancer using tumor explant models.

bioRxiv · Mar 2, 2023Cancer Biology

Molecular Pathophysiology of Cardiac Injury and Cardiac Microthrombi in Fatal COVID-19: Insights from Clinico-histopathologic and Single Nuclei RNA Sequencing Analyses

N. Fukuma, M. L. Hulke, M. I. Brener, S. Golob, R. Zilinyi, Z. Zhou, C. Tzimas, I. Russo, C. McGroder, R. Pfeiffer, A. Chong, G. Zhang, D. Burkhoff, M. B. Leon, M. Maurer, , E. J. Tsai

This study identifies transcriptomic changes in cardiac fibroblasts associated with cardiac microthrombi in fatal COVID-19 through single nuclei RNA sequencing and clinical analyses.

bioRxiv · Jul 27, 2021Pathology

Unbiased Assessment of H-STS cells as high-fidelity models for gastro-enteropancreatic neuroendocrine tumor drug mechanism of action analysis

M. J. Alvarez, P. Yan, M. L. Alpaugh, M. Bowden, E. Sicinska, C. W. Zhou, C. Karan, R. B. Realubit, P. S. Mundi, A. Grunn, D. Jäger, J. A. Chabot, A. T. Fojo, P. E. Oberstein, H. Hibshoosh, , A. Califano

The paper assesses H-STS cells as models for drug mechanism analysis in gastro-enteropancreatic neuroendocrine tumors using molecular criteria rather than histological features.

bioRxiv · Jun 23, 2019 · PreprintCancer Biology