R. Balaji

In silico and in vitro studies suggest epigallocatechin gallate (EGCG), a polyphenol in green tea, can bind and modulate the aggregation and cytotoxicity of the full-length TDP-43 protein implicated in TDP-43 proteinopathies.

This paper shows EGCG inhibits TDP-43 aggregation and cytotoxicity in vitro through binding to its C-terminal domain.

Shared enhancer gene regulatory networks between wound and oncogenic programs

The paper identifies shared enhancer gene regulatory networks in wound and oncogenic responses using Drosophila models.

A cell surface code mediates tissue-intrinsic defense against aberrant cells in epithelia

The paper identifies cell surface molecules that mediate tissue-intrinsic error correction by enabling epithelial cells to detect and remove aberrant neighbors.