A. Bajpai

In silico and in vitro studies suggest epigallocatechin gallate (EGCG), a polyphenol in green tea, can bind and modulate the aggregation and cytotoxicity of the full-length TDP-43 protein implicated in TDP-43 proteinopathies.

This paper shows EGCG inhibits TDP-43 aggregation and cytotoxicity in vitro through binding to its C-terminal domain.

Loss of Myeloid Cell-Specific β2-Adrenergic Receptor Expression Ameliorates Cardiac Function and Remodeling after Acute Ischemia

This study shows that deleting β2AR in myeloid cells improves cardiac function and reduces fibrosis after heart attack by enhancing efferocytosis of neutrophils.

Aging-associated Decline in Vascular Smooth Muscle Cell Mechanosensation is Mediated by Piezo1 Channel

This study shows that aging impairs vascular smooth muscle cell mechanosensation via Piezo1 hyperactivity, and inhibiting Piezo1 can alleviate vascular aging.

Nuclear biocondensate-forming lncRNA and cellular stress surveillance shape host cancer susceptibility

This study identifies hsr{omega} and its human homologs as key regulators of cancer susceptibility through stress response pathways in Drosophila and humans.

A Serpin27A-dependent Toll Signaling Underlies Host Genetics of Cancer Resistance in Drosophila

This study identifies a Serpin27A-dependent Toll signaling pathway in Drosophila that mediates cancer resistance through NF-κB-mediated tumor cell death.

A Drosophila model of oral peptide therapeutics for adult intestinal stem cell tumors

This paper evaluates the efficacy of a TONDU peptide in suppressing Yki-driven intestinal stem cell tumors in Drosophila by inhibiting YAP-TEAD interaction and modulating integrin signaling.

Phenylhydrazones are active against non-replicating Mycobacterium tuberculosis

This study shows that phenylhydrazones are active against non-replicating Mycobacterium tuberculosis, with some compounds showing enhanced activity under hypoxic conditions.