W. Deeksha

In silico and in vitro studies suggest epigallocatechin gallate (EGCG), a polyphenol in green tea, can bind and modulate the aggregation and cytotoxicity of the full-length TDP-43 protein implicated in TDP-43 proteinopathies.

This paper shows EGCG inhibits TDP-43 aggregation and cytotoxicity in vitro through binding to its C-terminal domain.

PAR recognition by PARP1 regulates DNA-dependent activities and independently stimulates catalytic activity of PARP1

This study identifies PAR reader domains in PARP1 and reveals that PAR stimulates PARP1 catalytic activity while inhibiting DNA-dependent activity through an allosteric mechanism.

UHRF1-SRA recognizes symmetric non-CG methylated DNA through dual-flip out of 5-methyl cytosines

This study shows UHRF1 SRA recognizes non-CG methylated DNA through a dual-flip mechanism, with different binding affinities for mCHG and mCG.