A. Bhargava

In silico and in vitro studies suggest epigallocatechin gallate (EGCG), a polyphenol in green tea, can bind and modulate the aggregation and cytotoxicity of the full-length TDP-43 protein implicated in TDP-43 proteinopathies.

This paper shows EGCG inhibits TDP-43 aggregation and cytotoxicity in vitro through binding to its C-terminal domain.

Divergent outcomes of SAK3, a T-type calcium channel enhancer, in two luminal-A type breast cancer cell lines: T-47D and MCF7

The paper shows that SAK3, a T-type calcium channel enhancer, causes different effects on proliferation and calcium levels in two luminal-A breast cancer cell lines.

Identifying perturbations that boost T-cell infiltration into tumours via counterfactual learning of their spatial proteomic profiles

The paper develops a deep-learning model to identify minimal tumour perturbations that enhance T-cell infiltration using spatial proteomic data from cancer samples.

Regulation of Lung Immune Tone by the Gut-Lung Axis via Dietary Fiber, Gut Microbiota, and Short-Chain Fatty Acids

This study shows that dietary fiber and gut microbiota influence lung immune tone via short-chain fatty acids, reducing inflammation and lung injury in mice.

Transcriptomic analysis of sorted lung cells revealed a proviral activity of the NF- κB pathway towards SARS-CoV-2

The paper analyzes transcriptomic data from sorted SARS-CoV-2 infected lung cells to show the NF-κB pathway promotes viral replication while CYLD inhibits it.

Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages

This study shows that Lamin A/C protects lung alveolar macrophages from nuclear envelope rupture and aging-related DNA damage, linking NE disruption to genomic instability and senescence.

Interactions between genes altered during cardiotoxicity and neurotoxicity in zebrafish revealed using induced network modules analysis

This study identifies gene interactions related to cardiotoxicity and neurotoxicity in zebrafish using induced network modules analysis of existing databases.

Replication Study: RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

This replication study confirms some findings of the original study on RAF inhibitors and their effects on MAPK pathway activation but reports discrepancies in key experiments.

Antimicrobial Agent Triclosan Inhibits Acetylcholinesterase Activity in Vitro in a Dose-Dependent Manner

This study shows triclosan inhibits acetylcholinesterase activity in vitro in a dose-dependent manner, suggesting a mechanism for its neurotoxic effects.

Stress and corticotropin releasing factor (CRF) promote necrotizing enterocolitis in a formula-fed neonatal rat model

This study shows that stress and CRF increase NEC risk in formula-fed neonatal rats, while CRF antagonism reduces NEC incidence and severity.

Inhibition of HIV infection by structural proteins of the inner nuclear membrane is associated with reduced chromatin dynamics

This study shows SUN1 and SUN2 inhibit HIV-1 and HIV-2 infection through distinct mechanisms involving chromatin dynamics and DNA damage response.

Silver nanoparticles induce a triclosan-like antibacterial action mechanism in multi-drug resistant Klebsiella pneumoniae

This study shows silver nanoparticles induce a triclosan-like antibacterial mechanism in multi-drug resistant Klebsiella pneumoniae by inhibiting fatty acid biosynthesis and causing oxidative stress.

The nucleus acts as a ruler tailoring cell responses to spatial constraints

The paper shows that the nucleus acts as a ruler by triggering contractile responses when confined, influencing cell migration and processes like cancer invasion and immune responses.

The conserved transcriptional regulator CdnL is required for metabolic homeostasis and morphogenesis in Caulobacter

This study shows that CdnL is essential for metabolic homeostasis and morphogenesis in Caulobacter crescentus by regulating biosynthetic gene expression and lipid II production.