Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity
E. Grajchen, M. Loix, P. Baeten, B. Cortereal, I. Hamad, M. Haidar, J. Dehairs, J. Broos, J. Ntambi, R. Zimmermann, R. Breinbauer, P. Stinissen, N. Hellings, G. Kooij, M. Giera, , J. F. J. Bogie
This study shows that SCD1 inhibits Treg differentiation and promotes autoimmunity by affecting fatty acid metabolism in an MS model.
bioRxiv · Jun 16, 2022Immunology