Author

P. J. Espenshade

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

B. I. Wieser· 1 shared C. Liu· 1 shared C. S. Kubota· 1 shared C. T. Ishida· 1 shared D. Mukhopadhyay· 1 shared G. Hoefler· 1 shared H. Reicher· 1 shared H. Wang· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

B. I. Wieser

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

SREBP-dependent regulation of lipid homeostasis is required for progression and growth of pancreatic ductal adenocarcinoma

C. T. Ishida, S. L. Myers, W. Shao, M. R. McGuire, C. Liu, C. S. Kubota, T. E. Ewachiw, D. Mukhopadhyay, S. Ke, H. Wang, Z. A. Rasheed, R. A. Anders, P. J. Espenshade

This study shows that SREBP pathway inhibition slows PDAC tumor growth by disrupting lipid homeostasis, suggesting SCAP as a therapeutic target.

Cancer Research Communications · Sep 27, 2024Peer-reviewedCancer Biology

Adipose Triglyceride Lipase is needed for homeostatic control of Sterol Element-Binding Protein-1c driven lipogenesis

B. I. Wieser, P. Pena de la Sancha, S. Schauer, H. Reicher, W. Sattler, R. Breinbauer, M. Schweiger, P. J. Espenshade, R. Zechner, G. Hoefler, P. W. Vesely

This study shows that ATGL-derived unsaturated FAs suppress SREBP-1c activation, linking lipolysis and lipogenesis through an ATGL/SREBP-1c axis.

bioRxiv · Nov 2, 2020 · PreprintBiochemistry