Author

R. C. Kennedy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Organism:mouse· 2 Approach:simulation· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

C. A. Hunt· 3 shared A. K. Smith· 2 shared G. E. P. Ropella· 2 shared L. Dutta· 2 shared P. Krishnan· 2 shared H. Jaeschke· 1 shared M. Marmor· 1 shared M. R. McGill· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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3 shared papersBioengineering

C. A. Hunt

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3 papers

Recent·Most cited

Utilizing virtual experiments to increase understanding of discrepancies involving in vitro-in vivo predictions of hepatic clearance

P. Krishnan, A. K. Smith, G. E. P. Ropella, L. Dutta, R. C. Kennedy, C. A. Hunt

This paper uses virtual experiments to investigate discrepancies between in vitro and in vivo predictions of hepatic drug clearance and identifies structural factors in the in vivo analog as a key determinant.

bioRxiv · Oct 9, 2020Bioengineering

Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms

A. K. Smith, G. E. P. Ropella, M. R. McGill, P. Krishnan, L. Dutta, R. C. Kennedy, H. Jaeschke, C. A. Hunt

The paper challenges four model mechanisms of ALT release from hepatocytes following APAP exposure in mice, finding one mechanism matches all validation targets quantitatively.

bioRxiv · Dec 24, 2019Pharmacology & Toxicology

Simulation Enabled Search for Explanatory Mechanisms of the Fracture Healing Process

R. C. Kennedy, M. Marmor, R. Marcucio, C. A. Hunt

This paper demonstrates the feasibility of using analogical simulation models to generate plausible explanations for fracture healing by achieving high similarity between simulated and actual histologic states.

bioRxiv · Nov 9, 2017Physiology