Author

C. A. Hunt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Bioengineering· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Approach:simulation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. K. Smith· 3 shared G. E. P. Ropella· 3 shared R. C. Kennedy· 3 shared L. Dutta· 2 shared P. Krishnan· 2 shared A. M. Neiman· 1 shared C. J. Slubowski· 1 shared D. Truong· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersPharmacology & Toxicology

A. K. Smith

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Utilizing virtual experiments to increase understanding of discrepancies involving in vitro-in vivo predictions of hepatic clearance

P. Krishnan, A. K. Smith, G. E. P. Ropella, L. Dutta, R. C. Kennedy, C. A. Hunt

This paper uses virtual experiments to investigate discrepancies between in vitro and in vivo predictions of hepatic drug clearance and identifies structural factors in the in vivo analog as a key determinant.

bioRxiv · Oct 9, 2020Bioengineering

A non-canonical Hippo pathway regulates spindle disassembly and cytokinesis during meiosis in Saccharomyces cerevisiae

S. M. Paulissen, C. A. Hunt, C. J. Slubowski, Y. Yu, D. Truong, X. Mucelli, H. T. Nguyen, S. Newman-Toledo, A. M. Neiman, L. S. Huang

This study identifies a non-canonical Hippo pathway in yeast meiosis II that regulates spindle disassembly and cytokinesis through SPS1 and CDC15.

bioRxiv · Feb 21, 2020Cell Biology

Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms

A. K. Smith, G. E. P. Ropella, M. R. McGill, P. Krishnan, L. Dutta, R. C. Kennedy, H. Jaeschke, C. A. Hunt

The paper challenges four model mechanisms of ALT release from hepatocytes following APAP exposure in mice, finding one mechanism matches all validation targets quantitatively.

bioRxiv · Dec 24, 2019Pharmacology & Toxicology

A Model Mechanism Based Explanation of an In Vitro-In Vivo Disconnect for Improving Extrapolation and Translation

A. K. Smith, Y. Xu, G. E. P. Ropella, C. A. Hunt

The paper uses virtual experiments to explain an in vitro-in vivo disconnect in acetaminophen toxicity by showing differing hepatocyte responses in culture versus mice due to sequential exposure.

bioRxiv · Nov 9, 2017Pharmacology & Toxicology

Simulation Enabled Search for Explanatory Mechanisms of the Fracture Healing Process

R. C. Kennedy, M. Marmor, R. Marcucio, C. A. Hunt

This paper demonstrates the feasibility of using analogical simulation models to generate plausible explanations for fracture healing by achieving high similarity between simulated and actual histologic states.

bioRxiv · Nov 9, 2017Physiology