Author

A. K. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:simulation· 1

Frequent Co-Authors

C. A. Hunt· 3 shared G. E. P. Ropella· 3 shared L. Dutta· 2 shared P. Krishnan· 2 shared R. C. Kennedy· 2 shared A. N. Kettenbach· 1 shared D. A. Hogan· 1 shared H. Jaeschke· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersPharmacology & Toxicology

C. A. Hunt

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Author profile →

4 papers

Recent·Most cited

The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway

J. Hollomon, Z. Liu, S. Rusin, N. P. Jenkins, A. K. Smith, K. Koeppen, A. N. Kettenbach, L. C. Myers, D. A. Hogan

This study identifies Ssn3 kinase substrates involved in hyphal growth repression through Flo8 phosphorylation in C. albicans.

bioRxiv · Jun 10, 2021Microbiology

Utilizing virtual experiments to increase understanding of discrepancies involving in vitro-in vivo predictions of hepatic clearance

P. Krishnan, A. K. Smith, G. E. P. Ropella, L. Dutta, R. C. Kennedy, C. A. Hunt

This paper uses virtual experiments to investigate discrepancies between in vitro and in vivo predictions of hepatic drug clearance and identifies structural factors in the in vivo analog as a key determinant.

bioRxiv · Oct 9, 2020Bioengineering

Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms

A. K. Smith, G. E. P. Ropella, M. R. McGill, P. Krishnan, L. Dutta, R. C. Kennedy, H. Jaeschke, C. A. Hunt

The paper challenges four model mechanisms of ALT release from hepatocytes following APAP exposure in mice, finding one mechanism matches all validation targets quantitatively.

bioRxiv · Dec 24, 2019Pharmacology & Toxicology

A Model Mechanism Based Explanation of an In Vitro-In Vivo Disconnect for Improving Extrapolation and Translation

A. K. Smith, Y. Xu, G. E. P. Ropella, C. A. Hunt

The paper uses virtual experiments to explain an in vitro-in vivo disconnect in acetaminophen toxicity by showing differing hepatocyte responses in culture versus mice due to sequential exposure.

bioRxiv · Nov 9, 2017Pharmacology & Toxicology