G. E. P. Ropella

This paper uses virtual experiments to investigate discrepancies between in vitro and in vivo predictions of hepatic drug clearance and identifies structural factors in the in vivo analog as a key determinant.

The paper challenges four model mechanisms of ALT release from hepatocytes following APAP exposure in mice, finding one mechanism matches all validation targets quantitatively.

The paper uses virtual experiments to explain an in vitro-in vivo disconnect in acetaminophen toxicity by showing differing hepatocyte responses in culture versus mice due to sequential exposure.