Author

H. Jaeschke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

A. K. Smith· 1 shared C. A. Hunt· 1 shared C. Slawson· 1 shared D. R. Robarts· 1 shared D. S. Umbaugh· 1 shared G. E. P. Ropella· 1 shared J. A. Hanover· 1 shared L. Dutta· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. K. Smith

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2 papers

Recent·Most cited

Regulation of Liver Regeneration by hepatocyte O-GlcNAcylation in mice

D. R. Robarts, S. R. McGreal, D. S. Umbaugh, W. S. Parkes, M. Kotulkar, S. Abernathy, N. Lee, H. Jaeschke, S. Gunewardena, S. A. Whelan, J. A. Hanover, N. E. Zachara, C. Slawson, U. Apte

This study shows that O-GlcNAcylation in hepatocytes is essential for proper liver regeneration, with its loss leading to uncontrolled proliferation and tumor formation.

bioRxiv · Oct 14, 2021Pathology

Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms

A. K. Smith, G. E. P. Ropella, M. R. McGill, P. Krishnan, L. Dutta, R. C. Kennedy, H. Jaeschke, C. A. Hunt

The paper challenges four model mechanisms of ALT release from hepatocytes following APAP exposure in mice, finding one mechanism matches all validation targets quantitatively.

bioRxiv · Dec 24, 2019Pharmacology & Toxicology