Author

R. Chahwan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell-cell communication· 2 Assay:DNA methylation· 2 Approach:microscopy & imaging analysis· 2

Frequent Co-Authors

A. Al Hrout· 2 shared R. Morrish· 2 shared A. Amin· 1 shared B. Peacock· 1 shared C. Tangcatherin· 1 shared E. C. Sheppard· 1 shared E. Tosti· 1 shared F. Palombo· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersImmunology

A. Al Hrout

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Assessing extracellular vesicles in human biofluids using flow-based analyzers

O. Krzyzaniak, K. Yim, A. Al Hrout, B. Peacock, R. Chahwan

This study compares the performance of two flow-based analyzers for extracellular vesicle phenotyping in human biofluids, finding that nanoFCM accurately analyzes small EVs and identifies underrepresented markers.

bioRxiv · Jul 20, 2022 · PreprintImmunology

Modelling liver cancer microenvironment: novel 3D culture system as a potential anti-cancer drug screening tool

A. Al Hrout, K. Cervantes-Gracia, R. Chahwan, A. Amin

This study develops a 3D co-culture model of liver cancer to better mimic in vivo tumor microenvironment and improve anti-cancer drug screening.

bioRxiv · Nov 4, 2021 · PreprintCancer Biology

Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice

S. Wang, K. Lee, S. Gray, Y. Zhang, C. Tangcatherin, R. Morrish, E. Tosti, J. van Oers, P. Cohen, T. MacCarthy, S. Roa, M. D. Scharff, W. Edelmann, R. Chahwan

This study compares Exo1DA/DA mice with nuclease-dead EXO1 to Exo1-/- and Exo1+/+ mice to show EXO1 has both enzymatic and scaffolding roles in DNA repair, immune response, and tumor suppression.

bioRxiv · Oct 5, 2021Cancer Biology

Single cell label-free probing of chromatin dynamics during B lymphocyte maturation

R. Morrish, K. H. W. Yim, S. Pagliara, F. Palombo, R. Chahwan, N. Stone

This study uses Raman microscopy to analyze chromatin dynamics in B lymphocytes, showing spectral analysis can complement RNA-seq for studying gene activation during maturation.

bioRxiv · Jan 12, 2021Biophysics

A universal fluorescence-based toolkit for real-time quantification of DNA and RNA nuclease activity

E. C. Sheppard, S. Rogers, N. J. Harmer, R. Chahwan

This paper introduces a fluorescence-based assay to measure nuclease activity, kinetics, and substrate preferences, applicable to DNA and RNA nucleases involved in repair and immune processes.

bioRxiv · Feb 14, 2019Biochemistry