Author

N. J. Harmer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Assay:proteomics· 2 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. L. Prior· 2 shared R. A. Field· 2 shared S. A. Nepogodiev· 2 shared A. E. Scott· 1 shared A. R. Cross· 1 shared A. Thomas· 1 shared B. D. Evans· 1 shared D. Salmon· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

J. L. Prior

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Survivor bias drives overestimation of stability in reconstructed ancestral proteins

A. Thomas, B. D. Evans, M. van der Giezen, N. J. Harmer

The paper shows that survivor bias, not consensus bias, explains the overestimation of stability in ancestral proteins reconstructed from extant sequences.

bioRxiv · Nov 23, 2022 · PreprintEvolutionary Biology

Spinning sugars in antigen biosynthesis: a direct study of the Coxiella burnetii and Streptomyces griseus TDP-sugar epimerases

A. R. Cross, S. Roy, M. Vivoli Vega, M. Rejzek, S. A. Nepogodiev, M. Cliff, D. Salmon, M. N. Isupov, R. A. Field, J. L. Prior, N. J. Harmer, Glycoengineering of Veterinary Vaccines (GoVV)

This paper studies the TDP-sugar epimerases in Coxiella burnetii and Streptomyces griseus, showing they perform the RmlC 3,5 double epimerisation activity and support TDP-rhamnose biosynthesis.

bioRxiv · Oct 25, 2021 · PreprintBiochemistry

Assessments of hepatitis B virus-like particles and Crm197 as carrier proteins in melioidosis glycoconjugate vaccines

M. Bayliss, G. Pergolizzi, M. I. Donaldson, A. E. Scott, S. A. Nepogodiev, L. Beales, M. Whelan, W. Rosenberg, H. Peyret, G. P. Lomonossoff, N. J. Harmer, T. Atkins, R. A. Field, J. L. Prior

This study compares the effectiveness of Crm197 and hepatitis B virus-like particles as carrier proteins for a melioidosis glycoconjugate vaccine, finding that Crm197 conjugates produce higher antibody titres but both protect against bacterial challenge.

bioRxiv · Apr 8, 2020 · PreprintImmunology

A universal fluorescence-based toolkit for real-time quantification of DNA and RNA nuclease activity

E. C. Sheppard, S. Rogers, N. J. Harmer, R. Chahwan

This paper introduces a fluorescence-based assay to measure nuclease activity, kinetics, and substrate preferences, applicable to DNA and RNA nucleases involved in repair and immune processes.

bioRxiv · Feb 14, 2019Biochemistry