NAMPT-derived NAD+ fuels PARP1 to promote skin inflammation through parthanatos
F. J. Martinez-Morcillo, J. Canton-Sandoval, F. J. Martinez-Navarro, I. cabas, I. Martinez-Vicente, J. Armistead, J. Hatzold, A. Lopez-Munoz, T. Martinez-Menchon, R. Corbalan-Velez, J. Lacal, M. Hammerschmidt, J. C. Garcia-Borron, A. Garcia-Ayala, M. L. Cayuela, , V. Mulero
This study shows that NAMPT-derived NAD+ fuels PARP1 to drive skin inflammation via parthanatos in psoriasis models.
bioRxiv · Feb 19, 2021Immunology