GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
R. Cordova, J. Misra, P. H. Amin, A. J. Klunk, N. P. Damayanti, K. R. Carlson, A. J. Elmendorf, K. Hyeong-Geug, E. T. Mirek, B. D. Elzey, M. J. Miller, X. C. Dong, L. Cheng, T. G. Anthony, R. Pili, , K. A. Staschke
This study shows GCN2 kinase supports prostate cancer growth by maintaining amino acid homeostasis, and a GCN2 inhibitor effectively reduces tumor growth in mouse models.
bioRxiv · Jun 17, 2022Cancer Biology