Author

T. G. Anthony

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

E. T. Mirek· 2 shared A. J. Elmendorf· 1 shared A. J. Klunk· 1 shared B. D. Elzey· 1 shared C. E. Bowman· 1 shared C. Jang· 1 shared J. D. Rabinowitz· 1 shared J. Misra· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersPharmacology & Toxicology

E. T. Mirek

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2 papers

Recent·Most cited

Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK

C. E. Bowman, M. D. Neinast, C. Jang, J. Patel, M. C. Blair, E. T. Mirek, W. O. Jonsson, Q. Chu, L. Merlo, L. Mandik-Nayak, T. G. Anthony, J. D. Rabinowitz, Z. Arany

This study shows that BT2, an inhibitor of BCKDK, reduces plasma tryptophan by displacing it from albumin, revealing an off-target effect on tryptophan metabolism.

bioRxiv · Mar 5, 2024Pharmacology & Toxicology

GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis

R. Cordova, J. Misra, P. H. Amin, A. J. Klunk, N. P. Damayanti, K. R. Carlson, A. J. Elmendorf, K. Hyeong-Geug, E. T. Mirek, B. D. Elzey, M. J. Miller, X. C. Dong, L. Cheng, T. G. Anthony, R. Pili, , K. A. Staschke

This study shows GCN2 kinase supports prostate cancer growth by maintaining amino acid homeostasis, and a GCN2 inhibitor effectively reduces tumor growth in mouse models.

bioRxiv · Jun 17, 2022Cancer Biology