Author

K. A. Staschke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

V. Calvo· 2 shared A. B. Wijeratne· 1 shared A. C. Rigby· 1 shared A. Chakraborty· 1 shared A. J. Elmendorf· 1 shared A. J. Klunk· 1 shared A. L. Mosley· 1 shared A. M. Runnebohm· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersCell Biology

V. Calvo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Inhibition of the Eukaryotic Initiation Factor-2-α Kinase PERK Decreases Risk of Autoimmune Diabetes in Mice

C. Muralidharan, F. Huang, J. R. Enriquez, J. E. Wang, J. B. Nelson, T. Nargis, S. C. May, A. Chakraborty, K. T. Figatner, S. Navitskaya, C. M. Anderson, V. Calvo, D. Surguladze, M. J. Mulvihill, X. Yi, , R. G. Mirmira

This study shows that inhibiting PERK reduces autoimmune diabetes risk in mice by decreasing β cell immunogenicity and improving islet function.

bioRxiv · Oct 6, 2023Cell Biology

Obtaining Increased Functional Proteomics Insights from Thermal Proteome Profiling through Optimized Melt Shift Calculation and Statistical Analysis

N. A. McCracken, H. Liu, A. M. Runnebohm, H. S. Wijeratne, A. B. Wijeratne, K. A. Staschke, A. L. Mosley

This study improves the InflectSSP pipeline for Thermal Proteome Profiling to enhance sensitivity and specificity in detecting proteome changes, demonstrating its effectiveness through reanalysis of datasets and a new UPR study.

bioRxiv · Dec 30, 2022 · PreprintBiophysics

GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis

R. Cordova, J. Misra, P. H. Amin, A. J. Klunk, N. P. Damayanti, K. R. Carlson, A. J. Elmendorf, K. Hyeong-Geug, E. T. Mirek, B. D. Elzey, M. J. Miller, X. C. Dong, L. Cheng, T. G. Anthony, R. Pili, , K. A. Staschke

This study shows GCN2 kinase supports prostate cancer growth by maintaining amino acid homeostasis, and a GCN2 inhibitor effectively reduces tumor growth in mouse models.

bioRxiv · Jun 17, 2022Cancer Biology

PERK inhibition blocks metastasis initiation by limiting UPR-dependent survival of dormant disseminated cancer cells

V. Calvo, W. Zheng, K. A. Staschke, A. R. Nobre, E. F. Farias, A. Nowacek, M. Mulvihill, A. C. Rigby, J. A. Aguirre-Ghiso

This study shows that PERK inhibition reduces metastasis by targeting dormant cancer cells through UPR-dependent mechanisms.

bioRxiv · Jul 30, 2021Cancer Biology