Author

J. Misra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

A. Gridnev· 1 shared A. J. Elmendorf· 1 shared A. J. Klunk· 1 shared B. D. Elzey· 1 shared E. T. Mirek· 1 shared H. Torabifard· 1 shared K. A. Staschke· 1 shared K. Hyeong-Geug· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperCancer Biology

A. Gridnev

Author profile →

3 papers

Recent·Most cited

Allosteric Modulation of YAP/TAZ-TEAD Interaction by Palmitoylation and Small Molecule Inhibitors

K. Mills, J. Misra, H. Torabifard

This study uses molecular dynamics simulations to investigate how palmitoylation and inhibitors affect YAP/TAZ-TEAD interactions, revealing distinct binding mechanisms for the inhibitor.

bioRxiv · Oct 24, 2023Biophysics

GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis

R. Cordova, J. Misra, P. H. Amin, A. J. Klunk, N. P. Damayanti, K. R. Carlson, A. J. Elmendorf, K. Hyeong-Geug, E. T. Mirek, B. D. Elzey, M. J. Miller, X. C. Dong, L. Cheng, T. G. Anthony, R. Pili, , K. A. Staschke

This study shows GCN2 kinase supports prostate cancer growth by maintaining amino acid homeostasis, and a GCN2 inhibitor effectively reduces tumor growth in mouse models.

bioRxiv · Jun 17, 2022Cancer Biology

Structure-based discovery of a novel small-molecule inhibitor of TEAD palmitoylation

J. Misra, A. Gridnev, S. Maity

This paper identifies a small-molecule inhibitor that targets TEAD palmitoylation, disrupting YAP-TEAD interaction and inhibiting cancer cell proliferation and migration.

bioRxiv · Jun 9, 2022Cancer Biology