Author

R. E. Iacob

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:structural biology· 3 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Organism:Drosophila· 1

Frequent Co-Authors

J. R. Engen· 3 shared B. Zhao· 2 shared T. A. Springer· 2 shared V. Q. Le· 2 shared Y. Tian· 2 shared C. Lu· 1 shared C. Toohey· 1 shared J. F. Pinello· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBiochemistry

J. R. Engen

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3 papers

Recent·Most cited

Protection of the prodomain 1-helix correlates with latency in the transforming growth factor- family

V. Q. Le, B. Zhao, R. E. Iacob, Y. Tian, C. Toohey, J. R. Engen, T. A. Springer

The paper investigates the structural basis of latency in TGF-beta family members by comparing conformational states and hydrogen-deuterium exchange patterns across multiple family members.

bioRxiv · Jun 24, 2021Biophysics

Fusion surface structure, function, and dynamics of gamete fusogen HAP2

J. Feng, X. Dong, J. F. Pinello, J. Zhang, C. Lu, R. E. Iacob, J. R. Engen, W. J. Snell, T. Springer

This study characterizes the structure, function, and dynamics of the gamete fusogen HAP2, revealing dynamic regions and structural features critical for fusion.

bioRxiv · May 16, 2018Biochemistry

Tolloid cleavage activates latent GDF8 by priming the pro-complex for dissociation

V. Q. Le, R. E. Iacob, Y. Tian, W. McConaughy, J. Jackson, Y. Su, B. Zhao, J. R. Engen, M. Pirruccello-Straub, T. A. Springer

This study shows Tolloid cleavage activates latent GDF8 by destabilizing prodomain-growth factor interfaces and priming the growth factor for release.

bioRxiv · Aug 3, 2017Biochemistry