Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression ofPAK3 via miRNA regulation
X. Tan, L. Tong, L. Li, J. Xu, S. Xie, L. Ji, J. Fu, Q. Liu, S. Shen, Y. Liu, Y. Xiao, F. Gao, R. E. Moses, N. Bardeesy, Y. Wang, , X. Li
This study shows that Smad4 loss promotes lung cancer metastasis by upregulating PAK3 through miRNA regulation, suggesting Smad4 LOF as a prognostic marker and therapeutic target.
bioRxiv · Apr 29, 2021Cancer Biology