S. Xie

VezA/vezatin facilitates proper assembly of the dynactin complex in vivo

This study identifies VezA/vezatin as a factor essential for dynactin complex assembly in Aspergillus nidulans, highlighting its role in connecting Arp1 mini-filament and pointed-end sub-complex.

Systematic perturbation screens decode regulators of inflammatory macrophage states and identify a role for TNF mRNA m6A modification

The paper identifies regulators of inflammatory macrophage states and shows that TNF mRNA m6A modification controls its stability and contributes to disease.

The G1/S transition in mammalian stem cells in vivo is autonomously regulated by cell size

This study shows that cell size autonomously regulates the G1/S transition in mammalian epidermal stem cells, independent of extracellular signals.

GGCX promotes Eurasian avian-like H1N1 swine influenza virus adaption to interspecies receptor binding

This study identifies GGCX as a key factor enabling EA H1N1 SIV adaptation to human-type -2,6 sialic acid receptors through HA carboxylation, suggesting it as a potential antiviral target.

Clearance of protein aggregates during cell division

The paper investigates how protein aggregates are cleared during cell division, finding that ER reorganization and BiP-mediated clearance occur during mitosis and cytokinesis.

Target-aware Molecule Generation for Drug Design Using a Chemical Language Model

This paper introduces TamGen, a chemical language model for target-aware molecule generation, and shows it produces high-quality compounds with inhibitory activity against Tuberculosis ClpP protease.

Forest demography and biomass accumulation rates are associated with transient mean tree size vs density scaling relations

The paper links mean tree size and density scaling relationships to biomass accumulation rates and demographic processes across forest biomes.

Dense Sampling of Taxa and Genomes Untangles the Phylogenetic Backbone of a Non-model Plant Lineage Rife with Deep Hybridization and Allopolyploidy

The paper constructs a robust phylogenetic backbone for the Campanuleae tribe using genomic data and phylogenetic methods, revealing hybridization and allopolyploidy as key drivers of diversification.

Inferring state-dependent diversification rates using approximate Bayesian computation (ABC)

This paper develops an ABC framework to estimate state-dependent diversification rates in the BiSSE model and evaluates its performance against likelihood-based methods.

Identifying summary statistics for approximate Bayesian computation in a phylogenetic island biogeography model

This study proposes summary statistics for approximate Bayesian computation in a phylogenetic island biogeography model and evaluates their performance against likelihood-based methods.

A phylogenomic approach, combined with morphological characters gleaned via machine learning, uncovers the hybrid origin and biogeographic diversification of the plum genus

This study combines phylogenomic and machine learning analyses to reveal hybrid origins and biogeographic diversification patterns in the plum genus.

Human FAM111A inhibits vaccinia virus replication by degrading viral DNA-binding protein I3 and is antagonized by poxvirus host range factor SPI-1

This study identifies FAM111A as a restriction factor for vaccinia virus and MVA, showing it degrades viral DNA-binding protein I3 and is counteracted by SPI-1.

miRNA-encoded regulatory peptides modulate cadmium tolerance and accumulation in rice

This study identifies miPEP156e, a miRNA-encoded peptide in rice, which enhances cadmium tolerance by modulating ROS and Cd transporter genes.

Lysine vitcylation is a novel vitamin C-derived protein modification that enhances STAT1-mediated immune response

This study identifies vitcylation, a novel vitamin C-derived protein modification, and shows it enhances STAT1-mediated immune response by inhibiting PTPN2 interaction and increasing IFN pathway activation in tumor cells.

Co-engagement of TIGIT+ immune cells to PD-L1+ tumours by a bispecific antibody potentiates T-cell response and tumour control

This paper shows that a bispecific antibody targeting PD-L1 and TIGIT enhances T-cell response and tumor control compared to using the individual antibodies.

Computational insights into the conformational transition of STING: mechanistic, energetic considerations, and the influence of crucial mutations

This study investigates the conformational transition of STING upon cGAMP binding, identifying mutations that affect the energetic landscape and suggesting V147L may not be a gain-of-function mutation.

Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules

This study develops an inducible mismatch repair system to identify targets of orphan cytotoxins by screening for compound resistance mutations in engineered cell lines.

High-throughput screening of functional neo-antigens and their specific TCRs via the Jurkat reporter system combine with droplet microfluidics

The paper develops a high-throughput platform for screening functional neo-antigens and their specific TCRs using droplet microfluidics and DNA barcoding.

Probing the hierarchical dynamics of DNA-sperm nuclear transition protein complex through fuzzy interaction and mesoscale condensation

This study investigates the hierarchical dynamics of TNP1-DNA interactions using computational and experimental methods to understand DNA condensation and its implications for vaccine design.

Japanese Encephalitis Virus NS1 Protein regulates the expression and distribution of TIM-1 to promote viral infection

This study shows that JEV NS1 protein increases TIM-1 expression and shifts its distribution to the cytoplasm, enhancing viral infection by reducing TIM-1-mediated restriction.

Perturbation of mitochondrial Ca2+ homeostasis activates cross-compartmental proteostatic response in Arabidopsis

This study shows that disrupting mitochondrial Ca2+ homeostasis in Arabidopsis leads to misregulated gene expression and proteostatic responses, affecting plant growth and stress resistance.

Aging and Obesity Prime the Methylome and Transcriptome of Adipose Stem Cells for Disease and Dysfunction

This study identifies epigenetic and transcriptomic changes in adipose stem cells due to aging and obesity, revealing synergistic effects and potential disease-related regulators.

Sister chromatid cohesion establishment during DNA replication termination

This study shows that sister chromatid cohesion is established during DNA replication termination by replisome-mediated pushing of pre-loaded cohesin complexes onto nascent DNA.

Circulating tumor DNA profiling approach based on in silico background elimination guides patient classification of multiple cancers

The paper introduces MaGIC, a ctDNA profiling method that improves cancer classification and chemosensitivity prediction by reducing background noise from cfDNA.

A simple island biodiversity model is robust to trait dependence in diversification and colonization rates

This study evaluates how trait-dependent diversification rates affect the accuracy of phylogenetic models on islands, finding that moderate rate differences do not significantly impact diversity metrics.

High Resolution Nanostructure with Two-stages of Exponential Energy Dissipation at the Ultrathin Osteochondral Interface Tissue of Human Knee Joint

The paper identifies an ultrathin calcified region in human knee osteochondral interface tissue with two-layered micro-nano structures and exponential modulus increase, enhancing energy dissipation and fatigue resistance.

The retromer complex regulates C. elegans development and mammalian ciliogenesis

This study shows the retromer complex is essential for C. elegans development and mammalian ciliogenesis, with a role in CP110 removal from the mother centriole.

Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression ofPAK3 via miRNA regulation

This study shows that Smad4 loss promotes lung cancer metastasis by upregulating PAK3 through miRNA regulation, suggesting Smad4 LOF as a prognostic marker and therapeutic target.

A T-cell independent universal cellular therapy strategy through antigen depletion

This paper demonstrates that non-T-cell based antigen depletion can induce apoptosis in CD19-expressing cancer cells, proposing a universal cellular therapy strategy using artificial antigen-recognizing cells.

Comprehensive analysis of hsa-miR-654-5p's tumor-suppressing functions

This study investigates the tumor-suppressing functions of hsa-miR-654-5p in lung cancer through bioinformatic analysis and in vitro experiments, revealing its role in inhibiting EMT, proliferation, and migration.