L. Tong

mTORC2-mediated cell-cell interactions promote BMP4-induced WNT activation and mesoderm differentiation

This study shows mTORC2 is required for BMP4-induced WNT activation and mesoderm differentiation through cell-cell interactions in hESCs.

Genome sequencing of 'Fuji' apple clonal varieties reveals evolutionary history and genetic mechanism of the spur-type morphology

The paper sequenced clonal Fuji apple varieties to uncover somatic variants linked to spur-type morphology and early maturation traits.

Beyond enumeration: Phenotype independent "labeling-capture-release" process enabling precise detection of circulating tumour cells and downstream applications

This paper introduces a labeling-capture-release method for isolating circulating tumor cells from blood samples with high efficiency and accuracy, enabling downstream applications.

The L-lactate dehydrogenases of Pseudomonas aeruginosa are conditionally regulated but both contribute to survival during macrophage infection

This paper investigates the regulation and role of L-lactate dehydrogenases LldD and LldA in Pseudomonas aeruginosa, showing they are conditionally expressed and contribute to survival during macrophage infection.

Temperature elevation synergises with and enhances the type-I IFN-mediated restriction of MPXV

This study shows that fever enhances the host's type-I IFN response to restrict MPXV replication.

In vitro methylation of the U7 snRNP subunits Lsm11 and SmE by the PRMT5/MEP50/pICln methylosome

This study identifies PRMT5-mediated methylation of Lsm11 and SmE in U7 snRNP, suggesting a role in its unique assembly.

Ticks; a reservoir for virus emergence at the human-livestock interface in Uganda

The paper sequences ticks in Uganda to identify viruses, finding 22 species including 8 pathogens and 5 novel viruses, with orthonairoviruses being prevalent.

The Interferon Resistance of Transmitted HIV-1 is a Consequence of Enhanced Replicative Fitness

The paper identifies that transmitted HIV-1's interferon resistance stems from enhanced replicative fitness rather than specific IFN resistance.

Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression ofPAK3 via miRNA regulation

This study shows that Smad4 loss promotes lung cancer metastasis by upregulating PAK3 through miRNA regulation, suggesting Smad4 LOF as a prognostic marker and therapeutic target.

A rationally designed c-di-AMP FRET biosensor to monitor nucleotide dynamics

This paper designs a FRET biosensor, CDA5, to detect c-di-AMP dynamics in bacteria, showing unimodal distribution and response changes in mutants.

Gut microbiome couples gut and brain during calorie restriction in treating obesity

This study shows that calorie restriction affects gut microbiome, which in turn influences metabolism, hormones, and brain function in obese individuals.

The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity

The paper shows the N439K SARS-CoV-2 spike variant maintains replication fitness while evading antibody neutralization.

Combination of ipratropium bromide and salbutamol in children and adolescents with asthma: a meta-analysis

This study evaluates the efficacy and safety of combining ipratropium bromide and salbutamol in children and adolescents with asthma, finding reduced hospital admissions but no significant adverse event differences.

INTS13 Mutations Causing a Developmental Ciliopathy Disrupt Integrator Complex Assembly

This study identifies mutations in INTS13 causing a ciliopathy by disrupting Integrator complex assembly and ciliogenesis.

Broad-spectrum virucidal activity of bacterial secreted lipases against flaviviruses, SARS-CoV-2 and other enveloped viruses

This study identifies two bacterial lipases with broad-spectrum antiviral activity against multiple enveloped viruses, including SARS-CoV-2, by disrupting viral envelopes.

Deletion of immune evasion genes provides an effective vaccine design for tumor-associated herpesviruses

This paper develops a herpesvirus vaccine by deleting immune evasion genes to enhance immunogenicity and safety, showing durable protection against latency in a mouse model.

Biophysical characterizations of the recognition of the AAUAAA polyadenylation signal

The paper characterizes the interactions between the AAUAAA polyadenylation signal and protein factors using fluorescence polarization, showing specific affinity and sequence requirements for recognition.

Identification of three sequence motifs in the transcription termination factor Sen1 that mediate direct interactions with Nrd1

The paper identifies three sequence motifs in Sen1 that directly interact with Nrd1's CID domain and characterizes these interactions structurally and functionally.

Molecular basis for the recognition of the human AAUAAA polyadenylation signal

The paper determines the cryo-EM structure of a human polyadenylation complex bound to AAUAAA RNA, revealing how this signal is recognized by CPSF-30 and WDR33.