Author

R. F. O'Shaughnessy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:proteomics· 3 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1

Frequent Co-Authors

C. Harwood· 1 shared E. A. O'Toole· 1 shared E. Camera· 1 shared E. M. Jones· 1 shared G. Youssef· 1 shared H. Tagoe· 1 shared J. A. McGrath· 1 shared J. Harper· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCancer Biology

C. Harwood

Author profile →

3 papers

Recent·Most cited

Loss of cholesterol in Junctional Epidermolysis Bullosa skin identifies a key role for Laminin-332 in actomyosin mediated cholesterol transport

E. M. Jones, E. Camera, P. Parzymies, S. T. Marsh, R. F. O'Shaughnessy, M. Aumailley, J. A. McGrath, E. A. O'Toole, M. P. Caley

This study shows that loss of Laminin-332 in JEB disrupts cholesterol transport in keratinocytes, affecting epidermal lipid metabolism and barrier function.

bioRxiv · Sep 10, 2023 · PreprintCell Biology

Phosphoproteomic analysis of the AKT signalling axis in cutaneous squamous carcinoma progression reveals novel therapeutic targets

R. Button, C. Harwood, R. F. O'Shaughnessy

This study identifies novel therapeutic targets in cutaneous squamous cell carcinoma by analyzing AKT signaling dynamics and phosphoproteomic changes across disease stages.

bioRxiv · Oct 3, 2022 · PreprintCancer Biology

Chronic activation of Toll-like receptor 2 induces an ichthyotic skin phenotype

H. Tagoe, S. Hassan, G. Youssef, K. Mills, J. Harper, R. F. O'Shaughnessy

This study identifies TLR2 activation as a common mechanism in ichthyosis, showing it induces hyperkeratosis and alters keratin expression through NFκB and Gata3 pathways.

bioRxiv · Jun 6, 2022Cell Biology