BiochemistrybioRxiv
Characterization of apo-form selective inhibition of indoleamine 2,3-dioxygenase.
R. F. Ortiz-Meoz, L. Wang, R. Matico…·G. Zhang
This study compares two IDO1 inhibitors, showing GSK5628 selectively inhibits apo-IDO1 by competing with heme, while epacadostat binds to the heme cofactor, leading to longer-lasting inhibition.
DOI 10.1002/cbic.202000298