Author

G. Bergamini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:deep learning· 1

Frequent Co-Authors

A. Rutkowska· 2 shared D. C. Sevin· 2 shared D. Poeckel· 2 shared D. Thomson· 2 shared J. Vappiani· 2 shared K. Strohmer· 2 shared A. Felici· 1 shared A. Halavatyi· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

A. Rutkowska

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Tackling Recalcitrant Pseudomonas aeruginosa Infections In Critical Illness via Anti-virulence Monotherapy

V. K. SINGH, M. Almpani, D. Maura, T. Kitao, L. Ferrari, S. Fontana, G. Bergamini, E. Calcaterra, C. Pignaffo, M. Negri, T. d. Oliveira Pereira, F. Skinner, M. Gkikas, D. Andreotti, A. Felici, , L. G. Rahme

This study identifies novel anti-MvfR compounds (NAMs) that reduce intestinal permeability and inflammation in Pseudomonas aeruginosa infections, offering a potential monotherapy for critical illness.

bioRxiv · Apr 27, 2022Microbiology

Characterization of apo-form selective inhibition of indoleamine 2,3-dioxygenase.

R. F. Ortiz-Meoz, L. Wang, R. Matico, A. Rutkowska, M. De la Rosa, S. Bedard, R. Midgett, K. Strohmer, D. Thomson, C. Zhang, M. Mebrahtu, J. Guss, R. Totoritis, T. Consler, N. Campobasso, , G. Zhang

This study compares two IDO1 inhibitors, showing GSK5628 selectively inhibits apo-IDO1 by competing with heme, while epacadostat binds to the heme cofactor, leading to longer-lasting inhibition.

bioRxiv · May 7, 2020Biochemistry

Multiomic and quantitative label-free microscopy-based analysis of ex vivo culture and TGFbeta1 stimulation of human precision-cut lung slices

M. M. Khan, D. Poeckel, A. Halavatyi, F. Stein, J. Vappiani, D. C. Sevin, C. Tischer, N. Zinn, J. D. Eley, N. S. Gudmann, T. Muley, H. Winter, A. J. Fisher, C. B. nanthakumar, G. Bergamini, R. Pepperkok

The paper uses multiomic and microscopy techniques to study fibrosis in human lung slices, showing increased collagen deposition with TGFbeta1 stimulation and a novel SHG-based method to quantify it.

bioRxiv · Dec 13, 2019Physiology

Proteome thermal stability reflects organ physiology and identifies drug-target engagement in vivo

J. Perrin, T. Werner, N. Kurzawa, D. D. Childs, M. Kalxdorf, A. Rutkowska, D. Poeckel, D. C. Sevin, E. Stonehouse, K. Strohmer, B. Heller, D. Thomson, J. Vappiani, J. Krause, H. C. Eberl, , G. Bergamini

This study introduces tissue-TPP and blood-CETSA to measure proteome thermal stability, revealing organ physiology and drug-target engagement in vivo.

bioRxiv · Dec 20, 2018 · PreprintCell Biology