Author

R. F. Place

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Organism:chicken / avian· 1 Research Focus:clustering· 1 Assay:CUT&Tag· 1

Frequent Co-Authors

C. Duan· 2 shared G. Li· 2 shared L.-C. Li· 2 shared M. Kang· 2 shared Z. Gan· 2 shared I. Schacht· 1 shared J. Chen· 1 shared K. Liu· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersPharmacology & Toxicology

C. Duan

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

RAG-17: A Novel siRNA Conjugate Demonstrating Efficacy in Late-Stage Treatment of SOD1G93A ALS mice

C. Duan, M. Kang, K. Liu, Z. Gan, G. Li, J. Chen, I. Schacht, R. F. Place, L.-C. Li

This study introduces RD-12500, an siRNA conjugate that effectively reduces SOD1 levels and delays disease progression in late-stage SOD1G93A ALS mice.

bioRxiv · Nov 23, 2023 · PreprintPharmacology & Toxicology

Local administration of a novel siRNA modality into the CNS extends survival and improves motor function in the SOD1G93A mouse model for ALS

C. Duan, M. Kang, X. Pan, Z. Gan, V. Huang, G. Li, R. F. Place, L.-C. Li

This study demonstrates that a novel siRNA modality, conjugated with an accessory oligonucleotide, improves survival and motor function in a mouse model of ALS when delivered locally to the CNS.

bioRxiv · Feb 27, 2023 · PreprintCell Biology