Author

O. Llorca

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Organism:Arabidopsis· 1 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Lopez-Perrote· 2 shared J. Boskovic· 2 shared M. Serna· 2 shared A. Gonzalez-Corpas· 1 shared A. Nicolas-Arago· 1 shared A. Palacios-Abella· 1 shared C. F. Rodriguez· 1 shared C. Garcia-Martin· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

A. Lopez-Perrote

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The structure of the R2T complex reveals a different architecture of the related HSP90 co-chaperones R2T and R2TP

A. Palacios-Abella, A. Lopez-Perrote, J. Boskovic, S. Fonseca, C. Urbez, V. Rubio, O. Llorca, D. Alabadi

The paper determines the cryoEM structure of the Arabidopsis R2T complex, revealing its dodecameric organization and distinct architecture compared to the human R2TP complex.

bioRxiv · Mar 27, 2024 · PreprintBiochemistry

Conserved Lysine in transmembrane helix 5 is key for the inner gating of the LAT transporter BasC

J. Fort, A. Nicolas-Arago, L. Maggi, M. Martinez-Molledo, D. Kapiki, N. Zijlstra, S. Bodoy, E. Pardon, J. Steyaert, O. Llorca, M. Orozco, T. Cordes, M. Palacin

This study identifies a conserved lysine in TM5 of BasC as critical for cytoplasmic gate dynamics, showing its role in gating transitions and modulation by substrates and mutations.

bioRxiv · Mar 26, 2024 · PreprintBiochemistry

CDK1 and PLK1 cooperate to regulate BICD2, dynein activation and recruitment to the nucleus as well as centrosome separation in G2/M

N. Gallisa-Sune, P. Sanchez-Fernandez-de-Landa, F. Zimmermann, M. Serna, J. Paz, L. Regue, O. Llorca, J. Luders, J. Roig

This study identifies CDK1 and PLK1-mediated phosphorylation of BICD2 as essential for dynein activation and nuclear processes during G2/M.

bioRxiv · Nov 4, 2021Cell Biology

Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone

M. Pal, H. Munoz-Hernandez, D. Bjorklund, L. Zhou, G. Degliesposti, J. M. Skehel, E. L. Hesketh, R. F. Thompson, L. H. Pearl, O. Llorca, C. Prodromou

The paper determines the cryo-EM structure of the human R2TP-TTT complex and shows how TTT recruits TOR to R2TP while regulating its chaperone activity.

bioRxiv · Nov 9, 2020Biochemistry

Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM

O. Llorca, A. Lopez-Perrote, N. Hug, A. Gonzalez-Corpas, C. F. Rodriguez, M. Serna, C. Garcia-Martin, J. Boskovic, R. Fernandez-Leiro, J. F. Caceres

The paper shows DHX34 interacts with RUVBL1-RUVBL2 and alters its conformation to reduce ATP hydrolysis, linking it to NMD activation.

bioRxiv · Sep 28, 2020Biophysics