R. Geller

Mapping the mutational landscape of a full viral proteome reveals distinct profiles of mutation tolerability

The paper maps mutation tolerability across a viral proteome, revealing structural and functional correlates and implications for drug target selection.

Genome data artifacts and functional studies of deletion repair in the BA.1 SARS-CoV-2 spike protein

This study examines deletion repair in the BA.1 SARS-CoV-2 spike protein, finding that such events are rare and have limited direct impact on viral evolution but may influence fitness-enhancing mutations.

Cell type-specific adaptation of the SARS-CoV-2 spike

This study shows how SARS-CoV-2 spike protein adapts to different human cell types through mutations that affect entry efficiency and receptor affinity.

An efficient plasmid-based system for the recovery of recombinant vesicular stomatitis virus encoding foreign glycoproteins

This paper describes an efficient plasmid-based system for producing recombinant VSV encoding foreign glycoproteins, validated with glycoproteins from multiple viral families.

Comprehensive profiling of polyclonal sera targeting a non-enveloped viral capsid

This study profiles polyclonal sera targeting a non-enveloped viral capsid, revealing variation in neutralization sites among humans and homogeneity in mice, and identifies structural and evolutionary parameters predictive of immune escape.

Identification of cytoplasmic chaperone networks relevant for respiratory syncytial virus replication

This study identifies chaperones and co-chaperones involved in RSV replication using RNAi screening and shows that VCP inhibition disrupts RSV replication.

Globally defining the effects of mutations in a picornavirus capsid

The paper defines the effects of mutations in a picornavirus capsid by analyzing >90% of single amino acid mutations, identifying sequence determinants, and developing a bioinformatic approach to predict host protein targets.

Hsp90 dictates viral sequence space by balancing the evolutionary tradeoffs between protein stability, aggregation and translation rate

The paper shows that reducing Hsp90 activity increases viral sequence diversity by altering the balance between protein stability, aggregation, and translation rate.