B. Alvarez-Rodriguez

Mapping the mutational landscape of a full viral proteome reveals distinct profiles of mutation tolerability

The paper maps mutation tolerability across a viral proteome, revealing structural and functional correlates and implications for drug target selection.

Lymphocytic choriomeningitis arenavirus requires cellular COPI and AP-4 complexes for efficient replication and virion production.

This study identifies COPI and AP-4 cellular complexes as essential for LCMV replication and virion production, acting in late stages of the viral life cycle.

Comprehensive profiling of polyclonal sera targeting a non-enveloped viral capsid

This study profiles polyclonal sera targeting a non-enveloped viral capsid, revealing variation in neutralization sites among humans and homogeneity in mice, and identifies structural and evolutionary parameters predictive of immune escape.

The structure of a native orthobunyavirus ribonucleoprotein reveals a key role for viral RNA in maintaining its helical architecture

This paper determines the 3D structure of a native bunyavirus ribonucleoprotein (RNP) using cryo-EM, revealing a helical architecture stabilized by RNA rather than longitudinal contacts between nucleoprotein monomers.