Author

M. Coscolla

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

S. Gagneux· 3 shared C. Beisel· 2 shared C. Loiseau· 2 shared D. Brites· 2 shared D. Yeboah-Manu· 2 shared P. Ruiz-Rodriguez· 2 shared S. Borrell· 2 shared A. Asante-Poku· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersMicrobiology

S. Gagneux

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Host-strain compatibility influences transcriptional responses in Mycobacterium tuberculosis infections

P. Ruiz-Rodriguez, M. Caballer-Gual, G. Santamaria, H. Hiza, M. Coscolla

This study shows that host-strain compatibility in Mycobacterium tuberculosis infections leads to distinct transcriptional responses, with compatible combinations showing higher infection rates and shared pathways related to host proliferation.

bioRxiv · May 21, 2024 · PreprintMicrobiology

Genome data artifacts and functional studies of deletion repair in the BA.1 SARS-CoV-2 spike protein

M. Alvarez-Herrera, P. Ruiz-Rodriguez, B. Navarro-Dominguez, J. Zulaica, B. Grau, M. A. Bracho, M. Guerreiro, C. Aguilar-Gallardo, F. Gonzalez-Candelas, I. Comas, R. Geller, M. Coscolla

This study examines deletion repair in the BA.1 SARS-CoV-2 spike protein, finding that such events are rare and have limited direct impact on viral evolution but may influence fitness-enhancing mutations.

bioRxiv · Jan 23, 2024Evolutionary Biology

Molecular epidemiology and whole genome sequencing analysis of clinical Mycobacterium bovis from Ghana

I. D. Otchere, A. J. van Tonder, A. Asante-Poku, L. Sanchez-Buso, M. Coscolla, S. Osei-Wusu, P. Asare, S. Y. Aboagye, S. A. Ekuban, A. I. Yahayah, A. Forson, A. Baddoo, C. Laryea, J. Parkhill, S. R. Harris, , D. Yeboah-Manu

This study analyzes Mycobacterium bovis isolates from Ghana using whole-genome sequencing to identify risk factors and genetic characteristics associated with bovine tuberculosis.

bioRxiv · Dec 6, 2018Microbiology

Reference Set of Mycobacterium tuberculosis Clinical Strains: A tool for research and product development

S. Borrell, A. Trauner, D. Brites, L. Rigouts, C. Loiseau, M. Coscolla, S. Niemann, B. De Jong, D. Yeboah-Manu, M. Kato-Maeda, J. Feldmann, M. Reinhard, C. Beisel, S. Gagneux

The paper introduces a reference set of 20 genetically characterized Mycobacterium tuberculosis clinical strains to enhance TB research by incorporating phylogenetic diversity beyond the commonly used lab strains.

bioRxiv · Aug 25, 2018Microbiology

A New Phylogenetic Framework for the Animal-adapted Mycobacterium tuberculosis Complex

D. Brites, C. Loiseau, F. Menardo, S. Borrell, M. B. Boniotti, R. Warren, A. Dippenaar, S. D. C. Parsons, C. Beisel, M. A. Behr, J. A. Fyfe, M. Coscolla, S. Gagneux

This study analyzes 529 MTBC genomes to reveal the phylogenetic relationships and evolutionary history of animal-adapted MTBC ecotypes, identifying four clades and suggesting host shifts and demographic factors drive host tropism.

bioRxiv · Aug 3, 2018Evolutionary Biology