Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzyme
C.-G. Wu, V. K. Balakrishnan, P. S. Parihar, K. Konovolov, Y.-C. Chen, R. A. Merrill, H. Wei, B. Carragher, R. Sundaresan, Q. Cui, B. E. Wadzinski, M. R. Swingle, A. Musiyenko, R. Honkanen, W. K. Chung, , Y. Xing
The paper investigates the structural and functional dynamics of the PP2A-B56δ holoenzyme, showing how mutations linked to intellectual disability affect its allosteric network and phosphorylation rates.
bioRxiv · Mar 9, 2023 · PreprintBiochemistry