Author

V. K. Balakrishnan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C.-G. Wu· 2 shared S. Strack· 2 shared Y. Xing· 2 shared A. Musiyenko· 1 shared A. P. Bravos· 1 shared A. Suzuki· 1 shared B. Carragher· 1 shared B. E. Wadzinski· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiochemistry

C.-G. Wu

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2 papers

Recent·Most cited

Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzyme

C.-G. Wu, V. K. Balakrishnan, P. S. Parihar, K. Konovolov, Y.-C. Chen, R. A. Merrill, H. Wei, B. Carragher, R. Sundaresan, Q. Cui, B. E. Wadzinski, M. R. Swingle, A. Musiyenko, R. Honkanen, W. K. Chung, , Y. Xing

The paper investigates the structural and functional dynamics of the PP2A-B56δ holoenzyme, showing how mutations linked to intellectual disability affect its allosteric network and phosphorylation rates.

bioRxiv · Mar 9, 2023 · PreprintBiochemistry

Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition

Y. Li, V. K. Balakrishnan, M. Rowse, C.-G. Wu, A. P. Bravos, V. K. Yadav, Y. Ivarsson, S. Strack, I. V. Novikova, Y. Xing

This study shows PME-1 demethylates PP2A holoenzymes and inhibits substrate recognition through structural interactions with the B56 subunit, revealing mechanisms of PME-1 activity and its role in p53 signaling.

bioRxiv · Jul 1, 2022Biochemistry