Nanobodies against C. difficile TcdA and TcdB reveal unexpected neutralizing epitopes and provide a toolkit for toxin quantitation in vivo
S. L. Kordus, H. K. Kroh, R. C. Rodriguez, R. A. Shrem, B. E. Wadzinski, D. B. Lacy, B. W. Spiller
This paper develops nanobodies against C. difficile toxins TcdA and TcdB, identifies neutralizing epitopes, and creates assays for in vivo toxin quantitation.
bioRxiv · Jun 21, 2023 · PreprintMicrobiology