Targeting Vitamin-D receptor (VDR) by a small molecule antagonist MeTC7 inhibits PD-L1 but controls THMYCN neuroblastoma growth PD-L1 independently
R. K. Singh, K. Kim, R. B. Rowswell-Turner, J. N. Hansen, N. Khazan, A. Jones, U. Sivagnanalingam, Y. Teramoto, T. Goto, Y. Jian, N. Battaglia, T. Conley, V. Hovanesian, N. Yano, R. Pandita, , R. Moore
This study shows that MeTC7, a VDR antagonist, reduces PD-L1 expression in cancer cells and inhibits neuroblastoma growth independently of PD-L1.
bioRxiv · Aug 16, 2020 · PreprintCancer Biology