A GPCR screening in human keratinocytes identifies that the metabolite receptor HCAR3 controls epithelial proliferation, migration, and cellular respiration.
M. P. Pedro, K. Lund, S. W. S. Kang…·R. Iglesias-Bartolome
This study identifies HCAR3 as a GPCR that regulates epithelial cell proliferation, migration, and respiration in human keratinocytes through altered metabolism and mitochondrial function.