Y. Yuan

A MSTNDel273C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia

This paper describes the creation of MSTNDel273C mutation with FGF5 knockout sheep using CRISPR/Cas9, resulting in skeletal muscle myofiber hyperplasia and a 'double-muscle' phenotype.

Glioma-associated fibroblasts promote glioblastoma resistance to temozolomide through CCL2-CCR2 paracrine signaling

This paper shows that glioma-associated fibroblasts enhance glioblastoma resistance to temozolomide by secreting CCL2, which activates the ERK1/2 pathway in cancer cells.

Damage sensing through TLR9 Regulates Inflammatory and Antiviral Responses During Influenza Infection

This study shows that TLR9 sensing of tissue damage during influenza infection promotes inflammation and antiviral responses, but its absence leads to impaired viral clearance and prolonged lung injury.

Efficient cloning of genes for wheat yield component traits from QTLs via sequencing of the RIL population

This study develops a method to clone genes for wheat yield traits by sequencing RIL populations, identifying and validating 11 candidate genes from 77 QTLs.

Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques

This study develops a HSV-vectored therapeutic vaccine that reactivates SIV latency and elicits immune responses, delaying viral rebound in SIV-infected macaques.

Phototropin connects blue light perception to starch metabolism in green algae

The paper identifies a blue light signaling pathway in green algae that inhibits starch accumulation via PMSK1 dephosphorylation and GAP1 repression.

Dysregulated SASS6 expression promotes increased ciliogenesis and cell invasion phenotypes

This study shows that overexpression of SAS-6 promotes ciliogenesis and cell invasion through YAP/TAZ pathway activation, linked to poor cancer prognosis.

In-silico Drug Repurposing pipeline for Epilepsy: Integrating Deep Learning and Structure-based Approaches

This paper develops an in-silico drug repurposing pipeline for epilepsy using deep learning and structure-based methods, identifying potential drugs with high binding affinity for epilepsy-related targets.

IL-1beta-induced epithelial cell and fibroblast transdifferentiation fuels neutrophil recruitment in chronic rhinosinusitis with nasal polyps

This study identifies IL-1beta-induced cell subsets that promote neutrophil recruitment in CRSwNP and shows IL-1beta inhibition reduces inflammation.

Deciphering the diversity and sequence of extracellular matrix and cellular spatial patterns in lung adenocarcinoma using topological data analysis

This study uses topological data analysis to quantify ECM architecture and spatial patterns in lung adenocarcinoma, revealing progressive changes linked to immune exclusion and metabolic shifts.

An Efficient and Safe Trans-complementation System for MPXV Mimicking Authentic Viral Infection

This paper develops a safe trans-complementation system for MPXV that mimics authentic infection, enabling research in lower biosafety labs without live virus.

Queuosine Salvage in Bartonella henselae Houston 1: A Unique Evolutionary Path

This study identifies a unique evolutionary pathway in Bartonella henselae for queuosine salvage, showing it can use both preQ1 and q, unlike other pathogens.

Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants

This study identifies a molecular mechanism by which amyloplast sedimentation triggers LAZY protein relocalization to mediate gravity sensing in Arabidopsis.

Modulation of Allostery with Multiple Mechanisms by Hotspot Mutations in TetR

This study evaluates allostery hotspot mutations in TetR using molecular dynamics simulations to understand their effects on allosteric coupling and functional free energy landscapes.

Histone variant H2A.Z is required for plant salt response by regulating gene transcription

This study shows H2A.Z regulates plant salt response by modulating gene transcription, with its occupancy affecting gene expression levels under salt stress.

Contact toxicity, antifeedant activity and oviposition preference of osthole against agricultural pests

This study evaluates the contact toxicity, antifeedant activity, and oviposition preference of osthole against three agricultural pests to assess its potential for pest control.

A Gpr35 tuned gut-brain metabolic axis regulates depressive-like behavior

This study identifies Gpr35 as a regulator of a gut-brain metabolic axis that influences depressive-like behavior in mice, highlighting microbial metabolites as potential therapeutic targets.

Coronavirus endoribonuclease nsp15 induces host cellular protein synthesis shutoff

This study shows that coronavirus nsp15 inhibits host protein synthesis and targets host mRNA, with EndoU activity essential for these effects and virus replication.

Dominant Role of Stochastic Processes in Soil Fungal Communities in Pioneer Forests at a Regional Scale

This study shows that stochastic processes dominate soil fungal community assembly in Populus davidiana forests, with elevation having a greater impact than seasonality.

Rigosertib promotes anti-tumor immunity via autophagic degradation of PD-L1 in colorectal cancer cells

Rigosertib promotes anti-tumor immunity by inducing autophagic degradation of PD-L1 in colorectal cancer cells, enhancing immune response and synergizing with checkpoint inhibitors.

Extensive diversity of RNA viruses in ticks revealed by metagenomics in northeastern China

The paper uses metagenomics to identify 22 RNA viruses in ticks from northeastern China, revealing novel species and highlighting public health risks from emerging tick-borne viruses.

Structural basis of sRNA RsmZ regulation of Pseudomonas aeruginosa virulence

This study determines the structure of RsmZ in complex with RsmA, revealing how RsmZ regulates virulence in Pseudomonas aeruginosa by modulating RsmA binding and gene expression.

FGFR1 governs iron metabolism via regulating post-translational modification of IRP2 in prostate cancer cells

This study shows FGFR1 promotes prostate cancer by enhancing iron metabolism through regulation of IRP2 post-translational modification and TFR1 expression.

The translational role of SOS1 in colorectal cancer

This paper investigates the role of SOS1 in colorectal cancer using patient-derived organoids and identifies SOS1 protein expression as a predictive marker for response to SOS1 inhibitors.

Long-term passaging of replication competent pseudo-typed SARS-CoV-2 reveals the antiviral breadth of monoclonal and bispecific antibody cocktails

This study evaluates the antiviral breadth of monoclonal and bispecific antibody cocktails against SARS-CoV-2 variants using a replication competent VSV-SARS-CoV-2 model, showing resistance to mutation in two cocktails.

Base Editor-Mediated Pooled Screening of Functional Mutations in Bacteria for Industrial Phenotypes

The paper develops a base editor-mediated pipeline in E. coli to screen for functional single nucleotide variants under industrial stress conditions, identifying known and novel mutations.

Streamlined, cell-specific single-molecule RNA-FISH of core clock mRNAs in clock neurons in whole mount Drosophila brains

The paper introduces a streamlined smFISH protocol and machine learning analysis to quantify Clock mRNA levels and localization in Drosophila clock neurons, showing cyclic mRNA counts in lLNvs.

Development of highly potent non-covalent inhibitors of SARS-CoV-2 3CLpro

This study develops a potent non-covalent inhibitor of SARS-CoV-2 3CLpro, showing effective antiviral activity in human cells and animal models.

Recovery of structural integrity of epithelial monolayer in response to massive apoptosis-induced defects

This study shows that epithelial monolayers recover structural integrity after apoptosis-induced defects through enhanced cell spreading, migration, and traction forces.

A human RNA ligase that operates via auto- and RNA-AMPylation

This study identifies C12orf29 as a human 5-3 RNA ligase that uses auto- and RNA-AMPylation to catalyze RNA ligation and maintain RNA integrity under stress.