K. B. Jensen

Deep Visual Proteomics advances human colon organoid models by revealing a switch to an in vivo-like phenotype upon xenotransplantation

The paper uses Deep Visual Proteomics to show that human colon organoids switch to an in vivo-like phenotype after xenotransplantation.

An integrated transcriptomic cell atlas of human endoderm-derived organoids

This paper creates a human endoderm organoid cell atlas by integrating single-cell transcriptomes from multiple organoid types to compare cell states with primary tissues and disease models.

Fibronectin meshwork controls epithelial stem cell fate

This study shows fibronectin in the hair follicle stem cell niche regulates regeneration by integrating signals through integrin and SLC3A2.

A biomechanical switch regulates the transition towards homeostasis in esophageal epithelium

The paper investigates how mechanical changes in the mouse esophagus regulate the transition to homeostasis by identifying a committed progenitor population through single-cell RNA sequencing and organ stretching experiments.

A semi-automated intestinal organoid screening method demonstrates epigenetic control of epithelial differentiation

This study develops a semi-automated intestinal organoid screening method to identify epigenetic regulators of epithelial differentiation, finding that inhibiting type I PRMTs enhances differentiation and blocks adenoma growth.

capCLIP: a new tool to probe protein synthesis in human cells through capture and identification of the eIF4E-mRNA interactome.

capCLIP captures and quantifies the eIF4E-mRNA interactome to measure translational activity, showing reduced TOP mRNA and altered eIF4E phosphorylation effects.