Author

R. J. M. Chan

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Biochemistry· 1

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Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

B. F. Cravatt· 1 shared C. Ritchie· 1 shared E. Njomen· 1 shared L. Li· 1 shared S. L. Ergun· 1 shared S. R. Lynch· 1 shared X. Cao· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

B. F. Cravatt

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1 paper

Recent·Most cited

Human STING oligomer function is governed by palmitoylation of an evolutionarily conserved cysteine

R. J. M. Chan, X. Cao, S. L. Ergun, E. Njomen, S. R. Lynch, C. Ritchie, B. F. Cravatt, L. Li

This paper identifies palmitoylation at C64 as critical for preventing unproductive STING oligomerization and shows a peptide inhibitor targeting the oligomerization interface.

bioRxiv · Aug 11, 2023 · PreprintBiochemistry