Author

E. Njomen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:drug response / drug discovery· 4 Assay:proteomics· 4 Approach:experimental assay· 3 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

B. Melillo· 3 shared S. J. Won· 3 shared B. Cravatt· 2 shared B. F. Cravatt· 2 shared D. Ogasawara· 2 shared H. Li· 2 shared K. DeMeester· 2 shared S. Schreiber· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiochemistry

B. Melillo

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Redirecting the pioneering function of FOXA1 with covalent small molecules

S. J. Won, Y. Zhang, C. J. Reinhardt, N. S. MacRae, K. E. DeMeester, E. Njomen, L. M. Hargis, J. R. Remsberg, B. Melillo, B. F. Cravatt, M. A. Erb

This study identifies covalent small molecules that bind FOXA1, altering its chromatin remodeling activity in prostate cancer cells.

bioRxiv · Mar 21, 2024Biochemistry

Chemical tools to expand the ligandable proteome: diversity-oriented synthesis-based photoreactive stereoprobes

D. Ogasawara, D. Konrad, Z. Y. Tan, K. Carey, J. Luo, S. J. Won, H. Li, T. Carter, K. DeMeester, E. Njomen, S. Schreiber, R. Xavier, B. Melillo, B. Cravatt

The paper introduces photo-stereoprobes for expanding the ligandable proteome and demonstrates their use in discovering bioactive small molecules.

bioRxiv · Feb 27, 2024Biochemistry

Human STING oligomer function is governed by palmitoylation of an evolutionarily conserved cysteine

R. J. M. Chan, X. Cao, S. L. Ergun, E. Njomen, S. R. Lynch, C. Ritchie, B. F. Cravatt, L. Li

This paper identifies palmitoylation at C64 as critical for preventing unproductive STING oligomerization and shows a peptide inhibitor targeting the oligomerization interface.

bioRxiv · Aug 11, 2023 · PreprintBiochemistry

Proteomic discovery of chemical probes that perturb protein complexes in human cells

M. Lazear, J. Remsberg, M. Jaeger, K. Rothamel, H.-l. Her, K. DeMeester, E. Njomen, S. Hogg, J. Rahman, L. Whitby, S. J. Won, M. Schafroth, D. Ogasawara, M. Yokoyama, G. Lindsey, , B. Cravatt

This study develops a proteomic strategy to identify chemical probes that perturb protein complexes in human cells by analyzing electrophilic compounds' effects on protein interactions.

bioRxiv · Dec 12, 2022Biochemistry

Enhancing c-MYC degradation via 20S proteasome activation induces in vivo anti-tumor efficacy

E. Njomen, T. Lansdell, A. Vanecek, V. Benham, M. Bernard, Y.-T. Yang, P. Schall, D. Isaac, O. Alkharabsheh, A. Al-Janadi, m. Giletto, E. Elsworth, C. Taylor, T. Yang, m. Bailie, , J. Tepe

This study shows that activating the 20S proteasome with small molecules reduces c-MYC-driven cancer growth in vitro and in vivo, including in bortezomib-resistant cells.

bioRxiv · Aug 24, 2020 · PreprintPharmacology & Toxicology