Author

S. R. Lynch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:imaging· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C. Khosla· 2 shared K. P. Yuet· 2 shared A. E. McShane· 1 shared A. Gomez· 1 shared A. Melville· 1 shared A. Noorani· 1 shared B. F. Cravatt· 1 shared B. L. Zhong· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

C. Khosla

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Human STING oligomer function is governed by palmitoylation of an evolutionarily conserved cysteine

R. J. M. Chan, X. Cao, S. L. Ergun, E. Njomen, S. R. Lynch, C. Ritchie, B. F. Cravatt, L. Li

This paper identifies palmitoylation at C64 as critical for preventing unproductive STING oligomerization and shows a peptide inhibitor targeting the oligomerization interface.

bioRxiv · Aug 11, 2023 · PreprintBiochemistry

Analysis of a "Split-and-Stuttering" Module of an Assembly Line Polyketide Synthase

K. M. Guzman, K. P. Yuet, S. R. Lynch, C. Liu, C. Khosla

The paper investigates a 'split-and-stuttering' module of a trans-AT PKS, showing it can catalyze up to five elongation cycles with a cis-configured central olefinic group after three cycles.

bioRxiv · Jan 15, 2021 · PreprintBiochemistry

CRIMSON: An Open-Source Software Framework for Cardiovascular Integrated Modelling and Simulation

C. J. Arthurs, R. Khlebnikov, A. Melville, M. Mar?an, A. Gomez, D. Dillon-Murphy, F. Cuomo, M. Silva Vieira, J. Schollenberger, S. R. Lynch, C. Tossas-Betancourt, K. Iyer, S. Hopper, E. Livingston, P. Youssefi, , C. A. Figueroa

CRIMSON is an open-source software framework for cardiovascular computational haemodynamics, enabling 3D and reduced-order simulations from medical images to clinical applications.

bioRxiv · Oct 14, 2020Bioengineering

Complete Reconstitution and Deorphanization of the 3 MDa NOCAP (NOCardiosis-Associated Polyketide) Synthase

K. P. Yuet, C. W. Liu, S. R. Lynch, J. Kuo, W. Michaels, R. B. Lee, A. E. McShane, B. L. Zhong, C. R. Fischer, C. Khosla

The paper reconstitutes and deorphanizes a nonamodular PKS from Nocardia strains, identifying the NOCAP aglycone structure through in vitro and heterologous expression methods.

bioRxiv · Jan 28, 2020Biochemistry