Author

S. L. Ergun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

L. Li· 2 shared B. F. Cravatt· 1 shared C. Ritchie· 1 shared D. Fernandez· 1 shared E. Njomen· 1 shared R. J. M. Chan· 1 shared S. R. Lynch· 1 shared T. M. Weiss· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

L. Li

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2 papers

Recent·Most cited

Human STING oligomer function is governed by palmitoylation of an evolutionarily conserved cysteine

R. J. M. Chan, X. Cao, S. L. Ergun, E. Njomen, S. R. Lynch, C. Ritchie, B. F. Cravatt, L. Li

This paper identifies palmitoylation at C64 as critical for preventing unproductive STING oligomerization and shows a peptide inhibitor targeting the oligomerization interface.

bioRxiv · Aug 11, 2023 · PreprintBiochemistry

STING polymer structure reveals mechanisms for activation, hyperactivation, and inhibition

S. L. Ergun, D. Fernandez, T. M. Weiss, L. Li

This study reveals how STING is activated, hyperactivated, and inhibited through structural and biochemical analysis of its polymerization mechanisms.

bioRxiv · Feb 15, 2019Biochemistry